NovaBone® Dental Putty in Cartridges
- Uni-dose cartridges and cartridge delivery system simplify bone graft handling and delivery
- 100% synthetic and resorbable Calcium Phosphosilicate dental putty
- Osteostimulative effect of material results in stimulation of osteoblast proliferation
- More than 20 years of clinical use and more than 50 scientific publications on file
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Unique Formulation
NovaBone® Dental Putty is 100% synthetic and fully resorbable. It is composed of calcium phosphosilicate (CPS) particles in a bimodal size distribution combined with a polyethylene glycol and glycerine binder. The binder improves handling and aids in maintaining the space between the particles, which facilitates revascularization after implantation. The bioactive CPS component makes up 70% of the putty by volume. Upon implantation, the water soluble binder is absorbed within 24 to 72 hours, creating a 3-dimensional porous scaffold that facilitates diffusion of blood and tissue fluids through the matrix. The smaller CPS particles (32-125 μm) are more rapidly resorbed, providing the initial burst of Ca and P ions. Subsequently, the larger particles (90-710 μm) react, and being more resistant to resorption, continue the process of bone regeneration.
Osteostimulative & Osteoconductive
Unlike most synthetic grafts that are only osteoconductive, bioactive NovaBone® Dental Putty also has an "osteostimulative" effect. After implantation, surface reactions result in absorption of the graft material, a controlled release of Si, Ca, and P ions, and concurrent new bone formation. These surface reactions result in an osteostimulative affect, defined as the stimulation of osteoblast proliferation in vitro as evidenced by increased DNA content and elevated osteocalcin and alkaline phosphatase levels. In vitro gene array analysis has confirmed that when human primary osteoblasts are exposed to extracts of CPS, upregulation of several gene families occurs.
Superior Delivery System & Handling
NovaBone® Dental Putty is available in multiple delivery options: trays, pre-filled syringes, and a unique industry-first cartridge delivery system. NovaBone® is the only graft material in the world that is available in disposable uni-dose cartridges. The cartridges simplify dispensing of the graft, especially in hard-to-reach areas, thus facilitating minimally invasive techniques (and hard-to-access defects such as gaps in immediate implant placement and crestal-approach sinus lifts). Cartridges are available in various sizes and are used in conjunction with NovaBone's® cartridge delivery system; each cartridge holds 0.25 cc's or 0.5 cc’s of putty.
NovaBone® Dental Putty significantly simplifies bone graft handling and delivery. It is ready to use and extremely user friendly. It is pre-mixed, cohesive, moldable, and adaptable. NovaBone® Dental Putty is stable at room temperature, does not require refrigeration, has a 4-year shelf-life, and appears radiodense on radiographs.
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Published Studies
Maxillary Sinus Augmentation Using Hydraulic Pressure by Lateral Approach and Simultaneous Implant Placement: Clinicoradiographic Study.
Bhandari S, Thomas R, Kumar T, Shah R, Mehta DS.
Implant Dent. 2019 Oct;28(5):514-519.
Alveolar Ridge Preservation with nc-HA and d-PTFE Membrane: A Clinical, Histologic, and Histomorphometric Study.
Laurito D, Lollobrigida M, Gianno F, Bosco S, Lamazza L, De Biase A.
Int J Periodontics Restorative Dent. 2017 Mar/Apr;37(2):283-290.
Evaluation of the bone regeneration potential of bioactive glass in implant site development surgeries: a systematic review of the literature.
Ioannou AL, Kotsakis GA, Kumar T, Hinrichs JE, Romanos G.
Clin Oral Investig. 2015 Mar;19(2):181-91
Clinical evaluation of 262 osseointegrated implants placed in sites grafted with calcium phosphosilicate putty: a retrospective study.
Babbush CA, Kanawati A.
J Oral Implantol. 2015 Feb;41(1):63-9.
Clinical and cone beam computed tomography comparison of NovaBone Dental Putty and PerioGlas in the treatment of mandibular Class II furcations.
Asmita, Gupta V, Bains VK, Singh GP, Jhingran R.
Indian J Dent Res. 2014 Mar-Apr;25(2):166-73.
Published Case Series
A simplified approach to the minimally invasive antral membrane elevation technique utilizing a viscoelastic medium for hydraulic sinus floor elevation.
Kotsakis GA, Mazor Z.
Oral Maxillofac Surg. 2015 Mar;19(1):97-101.
Posters
Osseodensification Crestal Sinus Floor Elevation with or without Synthetic and Resorbable Calcium Phosphosilicate Putty.
Rodrigo Neiva, D.D.S, M.S., Bruna Tanello, D.D.S., Wagner Duarte, D.D.S., PhD, Fred Silva D.D.S., Srinivas Katta, D.D.S., Salah Huwais, D.D.S.
Presented at 2017 EAO Congress, Madrid