NovaBone® Dental Putty in Syringe
- Uni-dose syringe delivery method allows clinician to clearly see how much bone graft is being used
- 100% synthetic and resorbable Calcium Phosphosilicate dental putty
- Osteostimulatory effect of material results in stimulation of osteoblast proliferation
- More than 20 years of international clinical use and more than 50 studies on file
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NovaBone® Syringe (0.5 CC)
NovaBone® Syringe (1.0 CC)
NovaBone® Syringe (2.0 CC)
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Unique Formulation
NovaBone® Dental Putty is 100% synthetic and fully resorbable. It is composed of calcium phosphosilicate (CPS) particles in a bimodal size distribution combined with a polyethylene glycol and glycerine binder. The binder improves handling and aids in maintaining the space between the particles, which facilitates revascularization after implantation. The bioactive CPS component makes up 70% of the putty by volume. Upon implantation, the water soluble binder is absorbed within 24 to 72 hours, creating a 3-dimensional porous scaffold that facilitates diffusion of blood and tissue fluids through the matrix. The smaller CPS particles (32-125 μm) are more rapidly resorbed, providing the initial burst of Ca and P ions. Subsequently, the larger particles (90-710 μm) react, and being more resistant to resorption, continue the process of bone regeneration.
Osteostimulative & Osteoconductive
Unlike most synthetic grafts that are only osteoconductive, bioactive NovaBone® Dental Putty also has an "osteostimulative" effect. After implantation, surface reactions result in absorption of the graft material, a controlled release of Si, Ca, and P ions, and concurrent new bone formation. These surface reactions result in an osteostimulative affect, defined as the stimulation of osteoblast proliferation in vitro as evidenced by increased DNA content and elevated osteocalcin and alkaline phosphatase levels. In vitro gene array analysis has confirmed that when human primary osteoblasts are exposed to extracts of CPS, upregulation of several gene families occurs.
Handling
NovaBone® Dental Putty significantly simplifies bone graft handling and delivery. It is ready to use and extremely user friendly. It is pre-mixed, cohesive, moldable, and adaptable. NovaBone® Dental Putty is stable at room temperature, does not require refrigeration, has a 4-year shelf-life, and appears radiodense on radiographs.
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Published Studies
Alveolar Ridge Preservation with nc-HA and d-PTFE Membrane: A Clinical, Histologic, and Histomorphometric Study.
Laurito D, Lollobrigida M, Gianno F, Bosco S, Lamazza L, De Biase A.
Int J Periodontics Restorative Dent. 2017 Mar/Apr;37(2):283-290.
Evaluation of the bone regeneration potential of bioactive glass in implant site development surgeries: a systematic review of the literature.
Ioannou AL, Kotsakis GA, Kumar T, Hinrichs JE, Romanos G.
Clin Oral Investig. 2015 Mar;19(2):181-91
Clinical evaluation of 262 osseointegrated implants placed in sites grafted with calcium phosphosilicate putty: a retrospective study.
Babbush CA, Kanawati A.
J Oral Implantol. 2015 Feb;41(1):63-9.
Clinical and cone beam computed tomography comparison of NovaBone Dental Putty and PerioGlas in the treatment of mandibular Class II furcations.
Asmita, Gupta V, Bains VK, Singh GP, Jhingran R.
Indian J Dent Res. 2014 Mar-Apr;25(2):166-73.
Posters
Osseodensification Crestal Sinus Floor Elevation with or without Synthetic and Resorbable Calcium Phosphosilicate Putty.
Rodrigo Neiva, D.D.S, M.S., Bruna Tanello, D.D.S., Wagner Duarte, D.D.S., PhD, Fred Silva D.D.S., Srinivas Katta, D.D.S., Salah Huwais, D.D.S.
Presented at 2017 EAO Congress, Madrid